Fig. 1

Time course of static mechanical allodynia (SMA) in the ipsilateral side to the injury (CCI-IoN) of 6 animal groups (each n = 8): CCI-IoN and its sham; 6-OHDA and its sham; and 6-OHDA + CCI-IoN and its sham. CCI-IoN animals showed a significant increase in the nocifensive score at post-surgery week 2 when compared to CCI-IoN-sham. The SMA score reached its maximum around the 4th week post-surgery and decreased slowly through the post-surgery observation period until week 12. SMA occurred rapidly within 3–4 days after 6-OHDA injection. This related SMA stayed significant when compared to sham for 7 weeks after the lesion. The highest nocifensive score was observed in the 6-OHDA + CCI-IoN group in comparison to all other groups. Despite the slight decrease observed along the 12 weeks post-surgery, the SMA score in this group remained significantly increased compared to all other groups. Comparison between CCI-IoN + 6-OHDA and CCI-IoN and 6-OHDA. Comparison between CCI-IoN and CCI-IoN sham. Comparison between CCI-IoN + 6-OHDA and CCI-IoN + 6-OHDA sham. Comparison between 6-OHDA and 6-OHDA sham. The bars represent standard deviation. *P < 0.05; **P < 0.01;***p < 0,001