Table 2 Univariate and multivariate analyses of the FA values in the different ROIs according to socio-demographic, clinical characteristics and CR
From: Right fronto-insular white matter tracts link cognitive reserve and pain in migraine patients
ANOVA | MANOVA | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Anterior Insula | Cingulate gyrus | Uncinate gyrus | Left | Right | |||||||
N | Left | Right | Left | Right | Left | Right | Wilks’ Lambda /F | p-value | Wilks’ Lambda/F | p-value | |
\( \overline{x}(sd) \) | \( \overline{x}(sd) \) | \( \overline{x}\ (sd) \) | \( \overline{x}\ (sd) \) | \( \overline{x}\ (sd) \) | \( \overline{x}(sd) \) | ||||||
Total | 0.64 (0.05) | 0.60 (0.06) | 0.75 (0.04) | 0.73 (0.05) | 0.66 (0.03) | 0.68 (0.04) | |||||
Sex | ** (0.0322) | 0.988/0.19 | 0.9036 | 0.873/2.32 | 0.0870 | ||||||
- Male | 5 | 0.63 (0.05) | 0.60 (0.05) | 0.75 (0.05) | 0.69 (0.04) | 0.66 (0.04) | 0.66 (0.06) | ||||
- Female | 47 | 0.64 (0.05) | 0.60 (0.06) | 0.75 (0.04) | 0.74 (0.05) | 0.67 (0.04) | 0.69 (0.03) | ||||
Assessment at baseline and 3 months | *(0.1793) | *(0.0987) | 0.924/0.63 | 0.7068 | 0.908/0.77 | 0.5929 | |||||
- Controls | 15 | 0.65 (0.05) | 0.61 (0.05) | 0.76 (0.04) | 0.75 (0.04) | 0.67 (0.03) | 0.69 (0.02) | ||||
- Episodics | 19 | 0.64 (0.04) | 0.59 (0.07) | 0.74 (0.04) | 0.74 (0.05) | 0.66 (0.03) | 0.68 (0.03) | ||||
- Chronic migraneurs | 18 | 0.63 (0.05) | 0.59 (0.06) | 0.75 (0.05) | 0.71 (0.05) | 0.66 (0.04) | 0.68 (0.05) | ||||
Assessment at 6 months | *(0.0645) | **(0.0457) | **(0.0274) | **(0.0170) | *(0.0645) | **(0.0274) | 0.666/3.34 | 0.0400 | 0.640/3.75 | 0.0276 | |
- Controls | 15 | 0.65 (0.05) | 0.61 (0.05) | 0.76 (0.04) | 0.75 (0.04) | 0.67 (0.03) | 0.69 (0.02) | ||||
- LTCM | 9 | 0.61 (0.05) | 0.57 (0.05) | 0.72 (0.04) | 0.70 (0.04) | 0.64 (0.04) | 0.65 (0.05) | ||||
Preventive therapy | ** (0.0115) | * (0.1261) | * (0.1358) | ** (0.0470) | ** (0.0420) | * (0.1192) | 0.851/2.79 | 0.0502 | 0.915/1.49 | 0.2288 | |
- No | 33 | 0.65 (0.04) | 0.61 (0.06) | 0.75 (0.04) | 0.74 (0.04) | 0.67 (0.03) | 0.69 (0.03) | ||||
- Yes | 19 | 0.62 (0.05) | 0.59 (0.05) | 0.74 (0.04) | 0.72 (0.05) | 0.65 (0.04) | 0.67 (0.04) | ||||
Cognitive reserve | ** (0.0097) | ** (0.0402) | ** (0.0202) | * (0.1497) | 0.731/1.71 | 0.0940 | 0.673/2.20 | 0.0268 | |||
- ≤11 | 13 | 0.63 (0.06) | 0.59 (0.04) | 0.76 (0.04) | 0.72 (0.05) | 0.66 (0.03) | 0.67 (0.04) | ||||
- 12–15 | 13 | 0.63 (0.05) | 0.56 (0.07) | 0.72 (0.05) | 0.71 (0.04) | 0.66 (0.04) | 0.67 (0.04) | ||||
- 16–18 | 15 | 0.65 (0.04) | 0.63 (0.03) | 0.75 (0.03) | 0.76 (0.04) | 0.67 (0.03) | 0.70 (0.03) | ||||
- >18 | 11 | 0.65 (0.05) | 0.62 (0.06) | 0.77 (0.02) | 0.74 (0.05) | 0.68 (0.04) | 0.69 (0.03) | ||||