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Fig. 2 | The Journal of Headache and Pain

Fig. 2

From: Dural administration of inflammatory soup or Complete Freund’s Adjuvant induces activation and inflammatory response in the rat trigeminal ganglion

Fig. 2

pERK immunohistochemistry on the TG. a. Negative control, showing no immunoreactivity. b. pERK1/2 staining in fresh animals. pERK positive nuclei (thin arrow) and nucleolei (thick arrow) can be detected. c. 24 h vehicle group shows weakly increased pERK1/2 immunoreactivity in the SGCs (thin arrow) and in the nucleolei (thick arrow). The TGs were studied at various time points (d-i). Positive immunoreactivity with different intensity can be detected in SGC (thin arrows) in all specimens. Negative SGC can also be seen (thick arrows). At 7 days CFA model, only few negative SGC were observed. Intensely stained nucleolei were also detected (arrow heads), more obvious at day 7 CFA. In the 7 days IS group, a lot of positive neuronal nuclei but no nucleolei were observed (asterisk)

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The Journal of Headache and Pain

ISSN: 1129-2377

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