Table 4 Calculated Ф values at 6, 12, and 18 h after administration
[Φ1B] | ||||
Drug | Dose (mg/time) (formulation) | 6 h after administration (%) | 12 h after administration (%) | 18 h after administration (%) |
Sumatriptan | 3 (subcutaneous injection) | 0 | 0 | 0 |
Zolmitriptan | 2.5 (oral tablet) | 76.3 | 36.1 | 3.3 |
Eletriptan | 20 (oral tablet) | 25.3 | 8.7 | 1.5 |
40 (oral tablet) | 52.9 | 25.7 | 11.4 | |
80 (oral tablet) | 75.7 | 43.6 | 20.7 | |
Rizatriptan | 10 (oral tablet) | 66.9 | 25.8 | 0 |
10 (RPD oral tablet) | 62.9 | 5.7 | 0 | |
Naratritpan | 1 (oral tablet) | 54.3 | 32.1 | 10 |
2.5 (oral tablet) | 78.2 | 57.7 | 57.7 | |
[Φ1D] | ||||
Drug | Dose (mg/time) (formulation) | 6 h after administration (%) | 12 h after administration (%) | 18 h after administration (%) |
Sumatriptan | 3 (subcutaneous injection) | 0 | 0 | 0 |
Zolmitriptan | 2.5 (oral tablet) | 90.7 | 63.1 | 33 |
Eletriptan | 20 (oral tablet) | 74.3 | 44.3 | 14.7 |
40 (oral tablet) | 90.7 | 75 | 50.7 | |
80 (oral tablet) | 96.4 | 87.1 | 67.1 | |
Rizatriptan | 10 (oral tablet) | 86.2 | 51.8 | 15 |
10 (RPD oral tablet) | 83.6 | 16.4 | 0 | |
Naratritpan | 1 (oral tablet) | 54.3 | 30.3 | 11.4 |
2.5 (oral tablet) | 77.8 | 57 | 29.3 | |