Table 3 Calculated duration time of Ф

Drug

Dose (mg/time) (formulation)

Time until Ф_1B became 50 % or less (hr)

Time until Ф_1B became 40 % or less (hr)

Time until Ф_1B became 30 % or less (hr)

Sumatriptan

3 (subcutaneous injection)

1.3

2.4

2.5

Zolmitriptan

2.5 (oral tablet)

9.6

11.3

13.1

Eletriptan

20 (oral tablet)

1.4

3.1

6.1

40 (oral tablet)

6.7

8.9

11.1

80 (oral tablet)

11

12.8

14.9

Rizatriptan

10 (oral tablet)

8

9.6

11.3

10 (RPD oral tablet)

7.2

8.1

9.2

Naratritpan

1 (oral tablet)

7.2

9.8

12.7

2.5 (oral tablet)

13.7

15.8

18

Drug

Dose (mg/time) (formulation)

Time until Ф_1D became 50 % or less (hr)

Time until Ф_1D became 40 % or less (hr)

Time until Ф_1D became 30 % or less (hr)

Sumatriptan

3 (subcutaneous injection)

1.3

2.4

2.5

Zolmitriptan

2.5 (oral tablet)

14.6

16.6

18.6

Eletriptan

20 (oral tablet)

10.9

12.8

14.9

40 (oral tablet)

18.3

21.2

24

80 (oral tablet)

22.9

26.7

31.1

Rizatriptan

10 (oral tablet)

12.2

13.8

15.5

10 (RPD oral tablet)

9.3

10.1

10.8

Naratritpan

1 (oral tablet)

7.2

9.7

12.7

2.5 (oral tablet)

12.4

15.6

17.9