Theoretical analysis of headache recurrence in patients administered triptans for migraine based on receptor occupancy

Table 1 Pharmacokinetic and pharmacodynamic parameters of triptans [12, 15, 19–24]

Drug (formulation)		t_1/2 (hr)	MW	f_u	Ki (nM)
Drug (formulation)		t_1/2 (hr)	MW	f_u	5-HT_1B	5-HT_1D
Sumatriptan (subcutaneous injection) [19]		1.46	295.40	0.66	12.59	12.59
Zolmitriptan (oral tablet)	Unchanged drug [12, 20]	2.40	287.30	0.75	^a6.31	^a2.51
Zolmitriptan (oral tablet)	Active metabolite [12, 20, 21]	2.35	273.36	0.75	^a1.58	^a0.50
Eletriptan (oral tablet) [22]		3.20	382.52	0.13	10.0	1.15
Rizatriptan (oral tablet) [23, 24]		1.60	269.35	0.86	7.24	2.34
Naratriptan (oral tablet) [15]		5.05	335.47	0.71	2.24	2.30

ISSN: 1129-2377