From: Two TRPV1 receptor antagonists are effective in two different experimental models of migraine
 | JNJ-38893777 | JNJ-17203212 |
---|---|---|
pIC50 (capsaicin) | 8.08 | 7.19 |
pIC50 (low pH) | 8.13 | 7.8 |
pK i (hTRPV1) | 8.0 | 7.3 |
Activity against related TRP channelsa | no activity (pIC50 < 5) | weak activity against cTRPM8 (pIC50 < 6) |
Activity against non-related channels or receptors | weak activity against: | no activity |
human Cholecystokinin 1 receptor (pK i 6.1) | ||
human Adenosine 3 receptor (pK i 6.2) | ||
rat cerebral cortex sodium channel (pK i 6.1) |