Hemodynamic characteristics of high-altitude headache following acute high altitude exposure at 3700 m in young Chinese men

Bian, Shi-Zhu; Jin, Jun; Li, Qian-Ning; Yu, Jie; Tang, Cai-Fa; Rao, Rong-Sheng; Yu, Shi-Yong; Zhao, Xiao-Hui; Qin, Jun; Huang, Lan

doi:10.1186/s10194-015-0527-3

Table 2 Differences between HAH+ and HAH- groups in demographics, systemic and cerebral hemodynamics (N = 363)

From: Hemodynamic characteristics of high-altitude headache following acute high altitude exposure at 3700 m in young Chinese men

Headache^a	HAH-	HAH+	HAH intensities			p (H+ vs. H-)
Cases(n)	(90)	(273)	Mild (215)	Moderate (52)	Sever (6)	p (H+ vs. H-)
Demographic factors
Age	22.59 ± 3.95	23.60 ± 4.48	23.12 ± 4.26	25.47 ± 4.99	25.00 ± 3.69	0.044*
BMI	21.52 ± 2.11	21.90 ± 2.61	21.85 ± 2.55	21.96 ± 2.89	23.56 ± 2.09	0.199
Smoking(yes)	20(22.2%)	66(24.2%)	52(24.2%)	11(21.2%)	3(50.0%)	0.705
Alcohol consumption(yes)	54(60.0%)	159(58.2%)	126 (58.6%)	28(53.8%)	5(83.3%)	0.796
Systemic hemodynamics
SBP	117.28 ± 11.62	118.66 ± 12.03	118.84 ± 12.38	118.17 ± 11.04	116.67 ± 7.76	0.340
DBP	77.52 ± 10.83	78.86 ± 9.97	78.89 ± 10.21	78.92 ± 9.26	77.33 ± 8.43	0.279
ΔBP	39.76 ± 7.14	39.80 ± 6.59	39.94 ± 7.04	39.25 ± 4.54	39.33 ± 5.24	0.958
MAP	90.77 ± 10.57	92.13 ± 10.24	92.21 ± 10.47	92.01 ± 9.65	90.44 ± 7.83	0.280
HR	84.41 ± 13.11	87.96 ± 13.02	87.35 ± 12.65	89.35 ± 13.26	98.00 ± 20.66	0.026*
SpO₂	88.70 ± 2.98	87.94 ± 3.19	88.16 ± 3.01	87.06 ± 3.81	87.83 ± 3.06	0.048*
LA	29.82 ± 2.12	29.70 ± 2.18	29.75 ± 1.99	29.40 ± 2.84	30.33 ± 2.50	0.632
LV	45.78 ± 2.27	46.00 ± 2.25	46.04 ± 2.21	45.85 ± 2.44	45.83 ± 2.32	0.425
RA	33.98 ± 2.04	34.10 ± 2.32	34.14 ± 2.27	34.06 ± 2.56	33.17 ± 2.32	0.661
RV	33.48 ± 2.24	33.70 ± 2.56	33.78 ± 2.56	33.50 ± 2.60	32.50 ± 2.07	0.469
PA	19.83 ± 1.14	19.95 ± 1.42	19.93 ± 1.42	19.98 ± 1.48	20.33 ± 1.03	0.452
EF	66.38 ± 4.28	67.16 ± 4.72	67.29 ± 4.82	66.87 ± 4.40	64.83 ± 3.31	0.165
SV	65.92 ± 8.96	67.32 ± 9.72	67.57 ± 9.79	66.66 ± 9.42	64.17 ± 10.63	0.230
CO	5.16 ± 1.14	5.60 ± 1.02	5.60 ± 1.03	5.65 ± 1.02	5.60 ± .663	0.001**
Tricuspid regurgitation	0.50(0.80)	0.50(0.60)	0.50(0.60)	0.50(0.80)	0.40(0.68)	0.135
Cerebral hemodynamics
Left side MCA
V_m	67.46 ± 12.18	67.41 ± 11.74	66.91 ± 10.87	69.35 ± 14.87	68.50 ± 11.47	0.973
V_s	102.17 ± 14.94	101.41 ± 15.91	100.79 ± 15.15	103.92 ± 18.83	102.00 ± 15.82	0.693
V_d	48.0 ± 10.12	47.96 ± 9.10	47.51 ± 8.37	49.46 ± 11.67	51.00 ± 8.60	0.964
PI	0.820 ± 0.169	0.800 ± 0.130	0.802 ± 0.127	0.799 ± 0.141	0.750 ± 0.130	0.260
RI	0.531 ± 0.063	0.527 ± 0.0490	0.528 ± 0.048	0.526 ± 0.051	0.499 ± 0.057	0.532
Left side VA
V_m	35.18 ± 5.57	36.38 ± 6.19	35.93 ± 5.66	37.63 ± 6.59	41.67 ± 14.40	0.103
V_s	51.28 ± 7.05	52.16 ± 8.49	51.75 ± 7.93	53.19 ± 9.20	57.83 ± 17.59	0.374
V_d	24.76 ± 4.76	25.96 ± 4.97	25.46 ± 4.49	27.35 ± 5.08	32.00 ± 11.93	0.045*
PI	0.765 ± 0.159	0.727 ± 0.153	0.738 ± 0.153	0.690 ± 0.150	0.640 ± 0.102	0.040*
RI	0.517 ± 0.065	0.500 ± 0.061	0.505 ± 0.058	0.482 ± 0.070	0.454 ± 0.053	0.025*
Right side MCA
V_m	63.51 ± 13.67	64.46 ± 11.45	64.24 ± 11.26	64.87 ± 11.57	68.67 ± 17.61	0.518
V_s	95.59 ± 17.61	96.24 ± 15.67	96.17 ± 15.55	96.13 ± 15.65	99.83 ± 22.29	0.740
V_d	45.11 ± 10.96	45.75 ± 8.73	45.53 ± 8.52	46.12 ± 8.95	50.67 ± 13.74	0.573
PI	0.812 ± 0.144	0.792 ± 0.124	0.796 ± 0.121	0.780 ± 0.125	0.734 ± 0.190	0.191
RI	0.530 ± 0.053	0.526 ± 0.051	0.527 ± 0.051	0.521 ± 0.047	0.493 ± 0.076	0.440
Right side VA
V_m	37.27 ± 6.18	37.27 ± 6.02	37.00 ± 5.80	38.63 ± 6.89	35.17 ± 4.66	0.991
V_s	52.51 ± 7.69	52.26 ± 8.29	52.11 ± 8.09	53.42 ± 9.21	47.50 ± 6.06	0.800
V_d	26.72 ± 5.09	26.55 ± 4.74	26.26 ± 4.56	27.75 ± 5.33	26.33 ± 4.89	0.764
PI	0.716 ± 0.208	0.693 ± 0.117	0.702 ± 0.117	0.669 ± .114	0.606 ± 0.056	0.202
RI	0.500 ± 0.119	0.491 ± 0.053	0.494 ± 0.052	0.480 ± .053	0.448 ± 0.037	0.317
BA
V_m	41.42 ± 8.64	44.18 ± 9.74	43.80 ± 9.42	46.33 ± 10.91	38.83 ± 8.06	0.017*
V_s	65.46 ± 11.54	68.81 ± 14.84	68.60 ± 14.32	70.81 ± 16.13	59.17 ± 19.63	0.028*
V_d	28.61 ± 7.46	30.47 ± 7.52	30.07 ± 7.31	32.29 ± 8.31	28.83 ± 6.27	0.042*
PI	0.914 ± 0.224	0.879 ± 0.193	0.890 ± 0.192	0.844 ± 0.183	0.760 ± .262	0.151
RI	0.564 ± 0.078	0.554 ± 0.068	0.559 ± 0.066	0.542 ± 0.069	0.496 ± .086	0.292
Asymmetry of the bilateral VAs
ΔV_s	−1.00 (8.00)	0. 00 (9.00)	0.00(9.00)	0.00 (10.50)	5.00 (28.5)	0.126
ΔV_d	−3.00 (6.25)	−1.00 (6.00)	−1.00(7.00)	−1.00 (3.75)	2.00 (18.5)	0.010*
ΔV_m	−2.50 (8.00)	−1.00 (6.00)	−1.00(6.00)	−1.00 (4.75)	1.00 (23.75)	0.046*
AI%	−6.6(22.0)	−2.7 (18.0)	−2.9(18.4)	−2.1(13.8)	2.8 (52.2)	0.040*
Conduction
CVCi	0.729 ± 0.145	0.724 ± 0.140	0.719 ± 0.135	0.737 ± 0.153	0.767 ± 0.191	0.758

*p is 0.05 or less, **p is 0.01 or less
HAH was characterized with higher velocity in posterior cerebral circulation and higher HR but lower SpO₂

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