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Figure 5 | The Journal of Headache and Pain

Figure 5

From: Short-lasting unilateral neuralgiform headache attacks with ispilateral facial flushing is a new variant of paroxysmal extreme pain disorder

Figure 5

Structural implications of the mutated SCN9A gene product. A) Multiple alignment of amino acid sequences from the S6 transmembrane segments in domain IV from human Nav1.2, 1.5, and 1.7 with the S6 pore-lining segment from NavAb [15]. B) Crystal structure of a voltage-gated sodium channel from Arcobacter butzleri (NavAb) (PDB code 3rvz) [15] viewed from the intracellular side of the membrane (left) and from the side (right), with the identified mutant position indicated.

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