Figure 5

Structural implications of the mutated SCN9A gene product. A) Multiple alignment of amino acid sequences from the S6 transmembrane segments in domain IV from human Na_v1.2, 1.5, and 1.7 with the S6 pore-lining segment from NavAb [15]. B) Crystal structure of a voltage-gated sodium channel from Arcobacter butzleri (NavAb) (PDB code 3rvz) [15] viewed from the intracellular side of the membrane (left) and from the side (right), with the identified mutant position indicated.