High sensitivity C-reactive protein and cerebral white matter hyperintensities on magnetic resonance imaging in migraine patients

Avci, Aynur Yilmaz; Lakadamyali, Hatice; Arikan, Serap; Benli, Ulku Sibel; Kilinc, Munire

doi:10.1186/1129-2377-16-9

Table 2 Anatomic location and distribution of juxtacortical, subcortical, and periventricular white matter hyperintensities in migraine and control subjects*

From: High sensitivity C-reactive protein and cerebral white matter hyperintensities on magnetic resonance imaging in migraine patients

White matter hyperintensities		Control (n = 216)		Migraine without aura (n = 143)		Migraine with aura (n = 73)		P ≤^†
Juxtacortical WMHs		0 (0)		12 (8.4)		6 (8.2)		.0001^‡
Juxtacortical WMHs	Frontal	0 (0)		7 (4.9)		3 (4.1)		.0001^‡
	Parietal	0 (0)		4 (2.8)		2 (2.7)		.03^‡
	Temporal	0 (0)		1 (0.7)		1 (1.4)		NS
	Occipital	0 (0)		0 (0.5)		0 (0.5)		-
Juxtacortical WMHs		0.0 ± 0.0	0 (0–0)	0.1 ± 0.48	0 (0–3)	0.14 ± 0.53	0 (0–3)	0.0001^‡
Juxtacortical WMHs	Frontal	0.0 ± 0.0	0 (0–0)	0.09 ± 0.41	0 (0–3)	0.05 ± 0.28	0 (0–2)	0.0001^‡
	Parietal	0.0 ± 0.0	0 (0–0)	0.04 ± 0.26	0 (0–2)	0.07 ± 0.42	0 (0–3)	.02^‡
	Temporal	0.0 ± 0.0	0 (0–0)	0.01 ± 0.08	0 (0–1)	0.01 ± 0.12	0 (0–1)	NS
	Occipital	0.0 ± 0.0	0 (0–0)	0.0 ± 0.0	0 (0–0)	0.0 ± 0.0	0 (0–0)	-
Subcortical WMHs		21 (9.7)		41 (28.7		24 (32.9)		.0001^‡
Subcortical WMHs	Frontal	20 (9.3)		36 (25.2)		22 (30.1)		.0001^‡
	Parietal	6 (2.8)		24 (16.8)		13 (17.8)		.0001^‡
	Temporal	0 (0)		2 (1.4)		4 (5.5)		.03^‡
	Occipital	0 (0)		1 (0.7)		0 (0)		-
Subcortical WMHs		0.34 ± 1.28	0 (0–10)	1.46 ± 2.9	0 (0–14)	1.60 ± 2.99	0 (0–13)	0.0001^‡
Subcortical WMHs	Frontal	0.31 ± 1.19	0 (0–10)	0.94 ± 1.99	0 (0–11)	1.10 ± 2.12	0 (0–11)	.0001^‡
	Parietal	0.03 ± 0.17	0 (0–1)	0.47 ± 1.32	0 (0–8)	0.42 ± 1.19	0 (0–8)	.0001^‡
	Temporal	0.0 ± 0.0	0 (0–0)	0.08 ± 0.36	0 (0–2)	0.08 ± 0.36	0 (0–2)	0.014^‡
	Occipital	0.0 ± 0.0	0 (0–0)	0.01 ± 0.17	0 (0–2)	0.0 ± 0.0	0 (0–0)	NS
Periventricular WMHs		0 (0)		0 (0)		3 (4.1)		.04^ǁ
Periventricular WMH	Anterior	0 (0)		0 (0)		3 (4.1)		.04^ǁ
	Posterior	0 (0)		0 (0)		0 (0)		-
	Lateral	0 (0)		0 (0)		0 (0)		-
Periventricular WMHs		0.0 ± 0.0	0 (0–0)	0.0 ± 0.0	0 (0–0)	0.04 ± 0.20	0 (0–1)	.02^ǁ
Periventricular WMHs	Anterior	0.0 ± 0.0	0 (0–0)	0.0 ± 0.0	0 (0–0)	0.04 ± 0.20	0 (0–1)	.02^ǁ
	Posterior	0.0 ± 0.0	0 (0–0)	0.0 ± 0.0	0 (0–0)	0.0 ± 0.0	0 (0–0)	-
	Lateral	0.0 ± 0.0	0 (0–0)	0.0 ± 0.0	0 (0–0)	0.0 ± 0.0	0 (0–0)	-

*Data reported as number of patients (%), mean ± SD, or median (range, minimum to maximum). Abbreviation: WMHs deep white matter hyperintensities.
^†NS, not significant (P > .05).
^‡Comparison between control subjects and migraine patients (with and without aura).
^ǁComparison between migraine patients with and without aura.

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