Table 1 Characteristics of participants in study of migraine*
Characteristic | Control (n = 216) | Migraine without aura (n = 143) | Migraine with aura (n = 73) | P ≤†| |
|---|---|---|---|---|---|
Age (y) | 32 ± 4.6 | 30.9 ± 7.6 | 32.6 ± 6.7 | NS | |
Body mass index (kg/m2) | 24.3 ± 3.3 | 24.4 ± 3.9 | 25 ± 4.1 | NS | |
Sex |  |  |  | .002‡ | |
Female | Â | 150 (69.4) | 105 (73.4) | 60 (82.2) | Â |
Male | Â | 66 (30.6) | 38 (26.6) | 13 (17.8) | Â |
hs-CRP (mg/L) | Mean ± SD | 0.82 ± 0.58 | 1.76 ± 1.86 | 2.31 ± 2.30 | .001‡ |
Median (min-max) | 0.69 (0.10-2.90) | 1.09 (0.10-9.51) | 1.48 (0.10-9.92) | ||
hs-CRP (no. of subjects [%]) | <1 mg/L | 147 (68.1) | 65 (45.5) | 28 (38.4) | .001‡ |
1-3 mg/L | 69 (31.9) | 53 (37.1) | 25 (34.2) | ||
>3 mg/L | 0 (0) | 25 (17.5) | 20 (27.4) | ||
WMHs present (no. of subjects [%]) | 21 (9.7) | 44 (30.8) | 25 (34.2) | .001‡ | |
No. of WMHs per subject | Mean ± SD | 0.34 ± 1.27 | 1.62 ± 3.07 | 1.66 ± 3 | .001‡ |
Median (min-max) | 0 (0–10) | 0 (0–16) | 0 (0–15) | ||
No. of subjects with WMHs | 0 WMH | 195 (90.3) | 99 (69.2) | 48 (65.8) | .001‡ |
1-2 WMHs | 8 (3.7) | 9 (6.3) | 4 (6.5) | ||
≥3 WMHs | 13 (6.0) | 35 (24.5) | 21 (28.8) | ||
Migraine disease duration (y) | Mean ± SD | - | 6.3 ± 5.2 | 10.1 ± 7 | .001§ |
Median (min-max) | - | 5 (1 – 30) | 10 (1 – 30) | ||
Headache localization | Half head | - | 47 (32.9) | 20 (27.4) | NS |
Entire head | - | 96 (67.1) | 53 (72.6) | ||
Visual analog score | Mean ± SD | - | 7.3 ± 1.8 | 7.8 ± 1.8 | NS |
Median (min-max) | - | 7 (3–10) | 8 (4–10) | ||
Headache frequency (no./mo) | Mean ± SD | - | 7.6 ± 5.6 | 7.7 ± 5.6 | NS |
Median (min- max) | - | 6 (2–20) | 5 (2–20) | ||
Headache duration (h) | Mean ± SD | - | 25,46 ± 27,69 | 26,11 ± 27,62 | NS |
Median (min - max) | - | 18.0 (1–168) | 18.0 (1–120) | ||
Medication | Acetaminophen | - | 41 (28.7) | 22 (30.1) | NS |
Nonsteroidal anti-inflammatory drug | - | 86 (60.1) | 41 (56.2) | ||
Ergotamine | - | 7 (4.9 | 8 (11) | ||
Triptan | - | 9 (6.3) | 2 (2.7) | ||
Education completed | Primary school | 21 (25.6) | 41 (28.9) | 24 (32.9) | NS |
Secondary school | 6 (7.3) | 15 (10.6) | 8 (11) | ||
High school | 29 (35.4) | 41 (28.9) | 22 (30.1) | ||
University | 26 (31.7) | 45 (31.7) | 19 (26) | ||
Family history of headache | 23 (28) | 110 (76.9) | 58 (79.5) | .001‡ | |
Smoking (≤1 pack/d) | 20 (24.4) | 35 (24.5) | 18 (24.7) | NS | |
Thyroid stimulating hormone (μIU/mL) | Median ± SD | 1.43 ± 0.73 | 1.42 ± 0.71 | 1.47 ± 0.77 | NS |
Median (min - max) | 1.26 (0.37-4.03) | 1.25 (0.35-3.90) | 1.41 (0.44-4.25) | ||
Ejection Fraction (%) | Median ± SD | 65.67 ± 4.76 | 65.24 ± 3.61 | 64.44 ± 4.33 | NS |
Median (min - max) | 65 (60–75) | 65 (60–74) | 65 (60–75) | ||