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Volume 15 Supplement 1

Abstracts from the 4th European Headache and Migraine Trust International Congress: EHMTIC 2014

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EHMTI-0328. Comparative evaluation of pregabalin, gabapentin, carbamazepine and topiramat in migraine

The Journal of Headache and Pain volume 15, Article number: G7 (2014) Cite this article

Objective

To compare the efficacy and safety of of pregabalin, gabapentin, carbamazepine and topiramat in migraine.

Research design and methods

In this observational study, 24 patients received pregabalin, gabapentin, carbamazepine and topiramat orally twice daily, each for 6 month with optional dose up titration (divided in four groups, each group has 6 patients). Pain diagnosis of migraine was made according to the second edition of the International Classification of Headache Disorders (ICHD-2) criteria and pain relief was measured by the patient’s global assessment of efficacy, using the Migraine Disability Assessment Questionnaire (MIDAS). Treatment goals include restoring function and improving pain control.

Results

There was a significant improvement in pain with all treatments compared with their baseline values. There were no significant differences in various other outcome measures between the groups.

Conclusions

Both carbamazepine and topiramat demonstrated similar efficacy in migraine but pregabalin, gabapentin was less effective on pain.

No conflict of interest.

Author information

Authors and Affiliations

  1. General Medicine, Ovidius University Constanta, Constanta, Romania

    A Docu Axelerad

  2. Kinetotherapy Department FEFS, Ovidius University Constanta, Constanta, Romania

    D Docu Axelerad

Authors
  1. A Docu Axelerad
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  2. D Docu Axelerad
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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Axelerad, A.D., Axelerad, D.D. EHMTI-0328. Comparative evaluation of pregabalin, gabapentin, carbamazepine and topiramat in migraine. J Headache Pain 15 (Suppl 1), G7 (2014). https://doi.org/10.1186/1129-2377-15-S1-G7

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  • DOI: https://doi.org/10.1186/1129-2377-15-S1-G7

Keywords

The Journal of Headache and Pain

ISSN: 1129-2377

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