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EHMTI-0061. Do the interictal microembolic signals have a role in higher cortical dysfunctions during migraine aura?

Introduction

Higher cortical functions (HCF) impairment during aura in migraine patients is more frequent than previously thought.

The aim of this study was to evaluate prevalence and clinical impact of interictal microembolic signals (MES) in migraine patients with HCF disturbances during aura.

Method

This study was carried out on 68 patients (34 migraineurs with higher cortical functions (HCF) disturbances during the aura (HCD group) and 34 migraineurs with only visual or visual and sensory symptoms (Control group I) and 31 healthy controls (Control group II). Demographic data, disease features and detected MES between these groups were analyzed. Furthermore, patients with HCF disturbances were analyzed according to presence of MES.

Results

There was no statistically significant difference in terms of gender, age at the time of examination and age at the time of the onset of disease between three groups. Aura was longer (34.71 ± 18.05 vs. 23.87 ± 13.64, p=0.002) and frequency of aura per year was higher (16.29 ± 14.21 vs. 10.10 ± 11.00, p=0.029) in the HCD group as compared to the Control group I. Also, sensory aura was significantly more present in HCD group (p<0.001). MES were detected in 10 (29.4%) patients from HCD group, which was significantly higher compared to 1 (3.2%) in Control group I and 2 (5.9%) in Control group II (χ2=7,909, p=0.005; χ2=6,476, p=0.011).

Conclusion

High prevalence and frequency is detected in migraine patients with HCF disturbances during aura. The exact pathophysiological mechanism of this finding is not clear and requires additional investigations.

No conflict of interest.

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Correspondence to A Podgorac.

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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Podgorac, A., Petrusic, I., Zidverc-Trajkovic, J. et al. EHMTI-0061. Do the interictal microembolic signals have a role in higher cortical dysfunctions during migraine aura?. J Headache Pain 15, E27 (2014). https://doi.org/10.1186/1129-2377-15-S1-E27

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Keywords

  • Public Health
  • Internal Medicine
  • Migraine
  • Demographic Data
  • Pathophysiological Mechanism