Skip to main content

EHMTI-0184. Ictal adiponectin levels are modulated by pain severity and treatment response in episodic migraineurs


Adiponection (ADP) and leptin (LEP) are adipokines with roles in inflammation.


To assess ADP and LEP levels before and after acute abortive treatment in episodic migraineurs (EM).


Peripheral blood specimens were collected from EM participants before and after acute abortive treatment with sumatriptan/naproxen sodium versus placebo.


A total of 34 participants (17 responders, 17 non-responders) were included. In all participants, for every 1 point increase in the HMW:T-ADP ratio, pain severity increased by 4.11 (CI: 0.44, 7.77; p=0.028). In responders (n=17), crude T-ADP levels were reduced at 30 min (11.49 ± 3.7; p=0.001), 60 min (11.54 ± 3.2; p=0.001) and 120 min (11.39 ± 3.7; p=0.001) after treatment as compared to onset (12.47 ± 3.6). In non-responders (n=17), crude T-ADP levels were unchanged after treatment. After adjustments, T-ADP levels remained decreased 30-120 min after treatment in responders; additionally, HMW-ADP, and the HMW:T-ADP ratio were decreased and LMW-ADP and the LMW:T-ADP ratio (coeff 0.04; CI: 0.01, 0.07; p=0.043) were increased 120 min after treatment in responders. In non-responders, the adjusted LMW-ADP (coef -0.45; CI: -0.77, -0.14; p=0.005) and the LMW:T-ADP ratio (coef -0.04; CI: -0.07, -0.01; p=0.018) were decreased at 60 min as well as at 120 min after treatment. Unadjusted and adjusted LEP levels were not modulated by changes in pain severity or treatment response.


Adiponectin, but not leptin, is associated with pain severity and is modulated by treatment response in episodic migraineurs.

Conflict of interest.

Author information



Corresponding author

Correspondence to NC Chai.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Chai, N., Gelaye, B., Tietjen, G. et al. EHMTI-0184. Ictal adiponectin levels are modulated by pain severity and treatment response in episodic migraineurs. J Headache Pain 15, E25 (2014).

Download citation


  • Public Health
  • Sodium
  • Placebo
  • Internal Medicine
  • Treatment Response