Skip to main content

EHMTI-0267. Plasma anandamide concentration after aerobic exercise training in healthy individuals and episodic migraine patients

Introduction

Anandamide (AEA) is an endocannabinoid operative in several biological functions. Nevertheless, it is not known the effect of aerobic exercise training (EXT) on plasma [AEA].

Aims

Because a dysfunctional endocannabinoid system has been suggested to underlie migraine (M) pathophysiology, we intended to explore the plasma [AEA] after EXT in M patients and healthy individuals.

Methods

EXT protocol consisted of 12-week of supervised treadmill at standardized intensity, performed 3 times/week, 30 min./session. Four groups were separated for intervention or waiting list: Healthy subjects without AET (CC), healthy subjects undergoing EXT (CEXE), M patients without EXT (MC), and M patients undergoing EXT (MEXE). Patients had episodic migraine with and without aura (ICHDII). Blood collections were performed interictally at least 24h after attacks or anti-inflammatory use. AEA was quantified by LC/MS/MS. All participants took no preventive medication.

Results

The study included 48 participants (12 for each group) and groups matched by age, sex, and BMI. Baseline [AEA] was not different between groups. AEA reduced in MEXE and CEXE, but was statistically significant only in CEXE (p = 0.007). There was a trend to a negative correlation between adherence and ΔAEA (r=-0.565, p = 0.056).

Conclusions

Plasma AEA decreases after EXT in healthy subjects. In M patients, this response is prevented by lower adherence. Future studies should investigate the relationship between exercise-reward and AEA.

* p = 0.007, Friedman´s Test

No conflict of interest.

Author information

Affiliations

Authors

Corresponding author

Correspondence to AB Oliveira.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Oliveira, A., Ribeiro, R., Mello, M. et al. EHMTI-0267. Plasma anandamide concentration after aerobic exercise training in healthy individuals and episodic migraine patients. J Headache Pain 15, E22 (2014). https://doi.org/10.1186/1129-2377-15-S1-E22

Download citation

Keywords

  • Future Study
  • Migraine
  • Negative Correlation
  • Healthy Subject
  • Healthy Individual