Skip to main content

EHMTI-0282. Deep brain stimulation in chronic cluster headache: lead location, clinical response and neuronal signatures

Background

Chronic Cluster Headache (CCH) is refractory to medical therapy in a small minority of patients. Neuroimaging implicateS the ipsilateral posterior hypothalamic region (PH) in its pathogenesis. PH deep brain stimulation (PH-DBS) has shown promise in the management of refractory CCH. Here we investigate the value of local field potentials (LFPs) in relation to the site of active DBS contact used for chronic stimulation.

Methods

Four patients with refractory CCH treated with PH-DBS were investigated. The target on stereotactic T2-weighted images lay in the anteromedial quadrant between the red nucleus and mammillary bodies. LFPs were recorded from externalised wires prior to implantation of the impulse generator a week after lead implantation.

Results

All leads were within 1.0mm of the intended target point. Mean(range) coordinates of the chronically active contact were 3.6(2.0-5.40)mm lateral, 3.1(1.2-5.0)mm posterior and 5.0(2.0-8.6)mm inferior to the midcommissural point. Mean follow-up was 23(15-26) months. Headache load was defined as the [severity (on the visual analogue scale)] x [duration] x [frequency]) of cluster headache. Headache load reduced by 57, 58, 68 and 100% in each patient. LFP peaks were noted in 3 out of 4 cases (at 8, 11 and 15Hz). The contacts used for stimulation at last follow-up coincided with one or both of the contacts affording the highest amplitude peak in bipolar recordings.

Conclusions

Our results support previous data that PH-DBS may be useful in patients with medically refractory cluster headache. LFP activity may potentially be useful in guiding contact selection during programming and deserves further investigation.

No conflict of interest.

Author information

Affiliations

Authors

Corresponding author

Correspondence to S Miller.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Miller, S., Rasul, F., Matharu, M. et al. EHMTI-0282. Deep brain stimulation in chronic cluster headache: lead location, clinical response and neuronal signatures. J Headache Pain 15, E19 (2014). https://doi.org/10.1186/1129-2377-15-S1-E19

Download citation

Keywords

  • Deep Brain Stimulation
  • Cluster Headache
  • Local Field Potential
  • Mammillary Body
  • Impulse Generator