- Meeting abstract
- Open Access
EHMTI-0156. Quantitative sensory testing in patients with headache attributed by idiopathic intracranial hypertension – a case-control study
The Journal of Headache and Pain volume 15, Article number: C65 (2014)
In patients with idiopathic intracranial hypertension (IIH) headache often persist as a disabling symptom even after intracranial pressure (ICP) has normalized. Yet very little is known about the mechanisms of chronification.
To explore pain perception in patients with IIH in a controlled design at time of diagnosis and after 3 months of treatment.
Materials and methods
We explored pain perception in patients with newly diagnosed IIH by Quantitative Sensory Testing (QST) measuring cephalic and extra-cephalic supra-threshold pain ratings and pain thresholds for pressure and electrical stimulation. QST was performed at diagnosis and after one and three months. ICP was measured at baseline and at the 3-month follow-up. QST measurements from sex-matched controls were used for comparisons. Headache was assessed by monthly standardized interviews and headache diaries.
At baseline IIH patients (n=28) showed no consistent abnormalities in pain sensitivity or thresholds (p>0.09 for all comparisons to healthy controls (n=28). Although headache improved markedly and ICP normalized in 52%, there was no consistent change in pain sensitivity from baseline to follow-up (p>0.09 for all variables). Patients with (54%) and without persistent chronic headache (46%) 3 months after diagnosis showed no different pain perception either at baseline or at the 3-month follow-up.
Although headache persisted as a chronic symptom in half of the patients we found no evidence of increased central pain sensitivity suggesting that headache chronification in IIH is caused by mechanisms other than central sensitization.
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Cite this article
Yri, H., Munksgaard, S., Bendtsen, L. et al. EHMTI-0156. Quantitative sensory testing in patients with headache attributed by idiopathic intracranial hypertension – a case-control study. J Headache Pain 15, C65 (2014). https://doi.org/10.1186/1129-2377-15-S1-C65
- Pain Threshold
- Intracranial Hypertension
- Central Sensitization
- Pain Perception
- Pain Sensitivity