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Volume 15 Supplement 1

Abstracts from the 4th European Headache and Migraine Trust International Congress: EHMTIC 2014

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EHMTI-0058. Association between Ala379Val polymorphism of lipoprotein-associated phospholipase A2 and migraine without aura in an Iranian population

The Journal of Headache and Pain volume 15, Article number: B41 (2014) Cite this article

Introduction

Migraine is a common neurovascular disorder with multifactorial and polygenic inheritance.

Aims

The aim of this study was to investigate the association of migraine without aura and Ala379Val polymorphism of lipoprotein-associated phospholipase A2 (Lp- PLA2) gene in an Iranian population.

Methods

In this study 103 migraine patients and 100 healthy controls were enrolled. DNA samples were extracted and the Ala379Val polymorphism of Lp-PLA2 gene was investigated. To assess severity of headache, patients filled out the HIT-6 and MIGSEV questionnaires.

Results

Allele V had significantly lower frequency in case group than control subjects (P=0.00, OR=0.25, CI=0.15 - 0.40). The frequency of migraine patients that were carrier of V allele (V/V and A/V) was statistically significant lower than control group (P=0.003, OR=2.39, CI: 1.35 - 4.23). There was no significant difference of alleles frequency between three grades of MIGSEV (P=0.316). Also total HIT-6 score was not significantly different between different genotypes (0.466).

Conclusion

In conclusion our results showed that Ala379Val gene polymorphism of Lp-PLA2 is associated with lower risk of migraine but not with severity of headaches.

No conflict of interest.

Author information

Authors and Affiliations

  1. Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    F Haghdoost, M Gharzi, E Hosseinzadeh & A Zandifar

  2. Pharmacy Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    F Faez

  3. Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    A Zandifar, S Zandifar & SH Javanmard

Authors
  1. F Haghdoost
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  2. M Gharzi
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  3. F Faez
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  4. E Hosseinzadeh
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  5. A Zandifar
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  6. S Zandifar
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  7. SH Javanmard
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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Cite this article

Haghdoost, F., Gharzi, M., Faez, F. et al. EHMTI-0058. Association between Ala379Val polymorphism of lipoprotein-associated phospholipase A2 and migraine without aura in an Iranian population. J Headache Pain 15 (Suppl 1), B41 (2014). https://doi.org/10.1186/1129-2377-15-S1-B41

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  • DOI: https://doi.org/10.1186/1129-2377-15-S1-B41

Keywords

The Journal of Headache and Pain

ISSN: 1129-2377

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