Figure 4

Release of biomarkers in the masseter muscle during experimental pain. Graph shows the release of serotonin (A), glutamate (B), glycerol (C), puruvate (D), lactate (E) and glucose (F) during the baseline (BL), experimental (Ex) and recovery (Rec) phases of the microdialysis. There was a significant increase of serotonin and glutamate on the hypertonic saline side over time (Friedman test; p < 0.05) and at time point 140 minutes compared to baseline (Bonferroni post-hoc test; p < 0.05), but no change on the control side. Glycerol increased significantly at the time point 140 minutes (Bonferroni post-hoc test; p < 0.05) on the hypertonic saline side but not the control side. The other substances; lactate, pyruvate and glucose show no significant increase.