Table 2 Comparison of demographic and clinical characteristics between responders and non-responders from placebo arm

Sex

 F

10

100

24

70.6

0.0853

 M

0

0

10

29.4

Age class (years)

 18-34

4

40

4

11.8

0.2563

 35-44

2

20

12

35.3

 45-54

3

30

14

41.2

 55-64

1

10

4

11.7

BMI class

 (<18) underweight

0

0

2

6.1

0.9166

 (18–24.9) normal weight

6

60

21

63.6

 (25–29.9) overweight

3

30

6

18.2

 (>30) obese

1

10

4

12.1

 NS

1

Comorbidity

 No

6

60

23

67.7

0.7138

 Yes

4

40

11

32.3

Surgery

 No

2

22.2

15

44.1

0.2807

 Yes

7

77.8

19

55.9

 Missing

1

Headache days/months (V1)

 15-25

6

60

20

58.8

1.000

 >25

4

40

14

41.2

Headache intensity (V1)

 Slight

1

10

1

2.9

0.1818

 Moderate

2

20

16

47.1

 Severe

7

70

17

50

Headache days/month (V2)

 <15

0

0

2

5.9

1.000

 15-25

6

60

20

58.8

 >25

4

40

12

35.3

Headache intensity (V2)

 Slight

0

0

3

8.8

0.2947

 Moderate

8

80

17

50

 Severe

2

20

14

41.2

Headache duration (years)

 0-10

2

20

5

14.7

0.0229

 11-20

1

10

6

17.6

 21-30

7

70

9

26.5

 >30

0

0

14

41.2

MOH duration (years)

 <1

1

10

5

14.7

0.9159

 1-3

4

40

11

32.4

 3-5

1

10

7

20.6

 >5

4

40

11

32.3

Overused drugs

 Analgesics >14d

3

30

12

35.3

0.7442

 Analgesics combinations >9d

2

20

5

14.7

 Drug combinations >9d

4

40

9

26.5

 Triptan combinations >9d

1

10

8

23.5