Figure 5

Kynurenate action at different parts of mouse trigeminal afferent neurons. A) Capsaicin-stimulated CGRP release from the dura mater was not altered by kynurenate (hemisected scull preparation, n = 8 each). B) Capsaicin-stimulated CGRP release from isolated intact trigeminal ganglia. Kynurenate did not induce a significant difference (n = 8). C) Capsaicin-stimulated CGRP release from brainstem slices was significantly reduced in the presence of kynurenate 2 mM (n = 15), applied during and before capsaicin application as indicated. Kynurenate alone did not alter basal CGRP release from the dura, the ganglion or the brainstem. Concentration-dependent inhibition of the increase in CGRP release by kynurenate is shown in the inset. Data are mean ± SEM. *p < 0.05.