Figure 3

Naratriptan action at different parts of mouse trigeminal afferent neurons. A) Capsaicin-stimulated CGRP release from the dura mater was not altered by naratriptan (hemisected scull preparation, n = 12 each). B) Capsaicin-stimulated CGRP release from isolated intact trigeminal ganglia. Naratriptan did not induce a significant difference (n = 12 each). C) Capsaicin-stimulated CGRP release from brainstem slices was significantly reduced in the presence of naratriptan (n = 13), applied during and before capsaicin application as indicated. Naratriptan alone did not alter basal CGRP release from the dura, the ganglion or the brainstem. The inset shows the inhibition of the increase in CGRP release by naratriptan. Data are mean ± SEM. *p < 0.05.