Figure 2

Concentration-dependence of capsaicin-induced CGRP release. A) Time course of the experiments, showing the concentration-dependent increase in CGRP for capsaicin ≥ 100 nM, which largely recovered within the subsequent 5 min (n = 6–14). B) For the increase in CGRP release (ΔCGRP), calculated between the values at 10 and 15 min, a fitted dose–response function had an EC₅₀ of 88 ± 5 nM. Data are mean ± SEM. *p < 0.05.