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Table 3 Diet effects on clinical measures, intention-to-treat analysis

From: Nutrition intervention for migraine: a randomized crossover trial

 

Diet period

Supplement period

Effect Sizee

p valuef

Baseline

16 weeks

Change

Baseline

16 weeks

Change

Mean (SD)

Mean (SD)

Mean (SD)

Mean (SD)

Mean (SD)

Mean (SD)

Mean (SD)

Body weight (kg) (N=42)

76.7 (20.2)

73.1 (19.4)

-3.6 (3.8)a

74.9 (19.7)

74.8 (19.9)

-0.1 (2.4)

-3.5 (4.4)

< 0.001

BMI (N=42)

27.5 (6.2)

26.2 (5.9)

-1.3 (1.3)a

26.9 (6.0)

26.8 (6.1)

0.0 (0.9)

-1.3 (1.6)

< 0.001

Total cholesterol (N=41)g

189.5 (38.8)

175.8 (42.7)

-13.7 (32.0)c

184.7 (33.6)

185.4 (38.0)

0.7 (26.2)

-14.4 (40.5)

0.03

HDL (N=42)

61.1 (15.7)

55.3 (14.3)

-5.8 (15.2)d

61.9 (14.1)

60.7 (14.3)

-1.2 (10.0)

-4.6 (19.0)

0.12

LDL (N=41)

108.8 (33.6)

99.8 (34.5)

-9.0 (26.3)d

103.1 (28.3)

105.5 (32.7)

2.3 (22.7)

-11.1 (33.6)

0.04

Ratio (N=41)

3.2 (0.9)

3.3 (0.9)

0.1 (0.8)

3.1 (0.7)

3.2 (0.8)

0.1 (0.7)

-0.1 (1.2)

0.75

Triglycerides (N=41)

95.9 (44.3)

102.7 (42.1)

6.8 (51.9)

96.3 (35.1)

96.2 (51.7)

-0.1 (49.2)

6.9 (77.6)

0.57

Log triglycerides (N=41)

1.94 (0.20)

1.98 (0.18)

0.04 (0.21)

1.96 (0.16)

1.94 (0.18)

-0.01 (0.15)

0.05 (0.28)

0.25

VAS (cm) (N=41)

6.0 (2.7)

3.8 (3.0)

-2.1 (3.2)b

4.9 (2.8)

4.2 (2.8)

-0.7 (2.3)

-1.4 (4.0)

0.03

Headache number (per wk) (N=40)h

2.1 (1.4)

1.8 (1.8)

-0.3 (1.2)

2.2 (2.1)

1.8 (2.2)

-0.4 (0.9)

0.1 (1.3)

0.61

Headache intensity (N=37)

4.3 (1.9)

3.3 (1.9)

-1.0 (1.7)c

3.8 (2.0)

3.3 (2.0)

-0.5 (1.5)

-0.5 (2.5)

0.20

Headache duration, hrs (N=38)

6.2 (4.0)

5.2 (4.0)

-0.9 (2.9)

5.2 (3.9)

4.8 (4.0)

-0.3 (2.5)

-0.6 (4.4)

0.44

Headache days (per wk) (N=40)

2.0 (1.4)

1.8 (1.5)

-0.3 (1.1)

2.1 (1.7)

1.7 (1.6)

-0.4 (0.8)

0.1 (1.3)

0.62

Medicated headache number (N=36)

1.4 (1.1)

1.1 (1.5)

-0.2 (1.5)

1.4 (1.5)

1.1 (1.1)

-0.3 (0.8)

0.0 (1.7)

0.90

% headaches medicated (N=36)

65.1 (33.5)

46.0 (32.7)

-19.2 (39.3)c

52.6 (32.4)

49.4 (34.4)

-3.2 (21.2)

-16.0 (48.5)

0.04

  1. Abbreviations: BMI Body Mass Index, HDL high-density lipoprotein cholesterol, LDL low-density lipoprotein cholesterol, Ratio= Total cholesterol/HDL, VAS visual analog pain scale, worst pain last 2 weeks, SD standard deviation.
  2. ap<0.0001, bp<0.001, cp<0.01, dp<0.05, all from within-group T-tests.
  3. eEffect size is difference between diet treatment effect and supplement treatment effect.
  4. fp value is from between group T-test.
  5. gOne participant with incomplete blood lipids data was excluded from analyses of total, HDL, and LDL cholesterol and triglycerides. Cholesterol and triglycerides are reported in mg/dl.
  6. hVariable Ns reflect the fact that participants with incomplete headache diary data were excluded from analysis of headache number, intensity, duration, days, and/or medication rates as appropriate.
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The Journal of Headache and Pain

ISSN: 1129-2377

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