Table 2 Genotype and allele distribution of the 5-HTTLPR polymorphisms among triptan responders (n = 102) and non-responders (n = 46)
From: Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache
Response status | Bi-allelic | |||||||
|---|---|---|---|---|---|---|---|---|
HWE | Genotype frequencies | p-value | Allele frequencies | p-value | ||||
LL (44) | LS (70) | SS (34) | L (158) | S (138) | ||||
Responders | 1.00 | 28.3 (29) | 50.0 (51) | 21.6 (22) | 0.61 | 0.53 (109) | 0.47 (95) | 0.98 |
Non-responders | 0.25 | 32.6 (15) | 41.3 (19) | 26.1 (12) | 0.53 (49) | 0.47 (43) | ||
Tri-allelic | ||||||||
HWE | Genotype frequencies | p-value | Allele frequencies | p-value | ||||
L*L* (37) | L*S* (70) | S*S* (41) | L* (144) | S* (152) | ||||
Responders | 0.56 | 26.5 (27) | 47.1 (48) | 26.5 (27) | 0.79 | 0.50 (102) | 0.50 (102) | 0.49 |
Non-responders | 0.78 | 21.7 (10) | 47.8 (22) | 30.4 (14) | 0.46 (42) | 0.54 (50) | ||