Validation of a guideline-based decision support system for the diagnosis of primary headache disorders based on ICHD-3 beta

Table 3 Statistical indices of clinical decision support system diagnostic performance

	Migraine				TTH				CH	MOH	NDPH
	MO	MA	CM	PM	iETTH	fETTH	CTTH	PTTH
Sensitivity (%)	99.38	100	95.24	62.71	92.31	98.02	90	60.87	90	100	100
(95% CI)	96.55- 99.89		77.33-99.15	49.95-73.92	66.69- 98.63	93.07-99.46	69.9-97.21	46.46-73.61	74.38-96.54	100	100
Specificity (%)	97.91	100	99.62	98.76	99.81	99.55	99.43	97.99	99.61	100	100
(95% CI)	95.93- 98.94		98.61-99.89	97.32-99.43	98.94-99.97	98.37- 99.88	98.33-99.8	96.34-98.9	98.59-99.89	100	100
Coincidence (%)	98.34	100	99.45	94.84	99.63	99.26	99.08	94.84	99.08	100	100
(95% CI)	96.88-99.13		98.39- 99.81	92.65-96.41	98.67-99.9	98.12-99.71	97.86-99.61	92.65-96.41	97.86-99.61	100	100
False negative rate	0.01	0	0.05	0.37	0.08	0.02	0.10	0.39	0.10	0	0
False positive rate	0.02	0	0.01	0.02	0.01	0.01	0.01	0.02	0.01	0	0
Youden index	0.97	1	0.94	0.61	0.92	0.98	0.89	0.59	0.90	1	1
PPV (%)	95.21	100	90.91	86.05	92.31	98.02	85.71	73.68	93.1	100	100
(95% CI)	90.83-97.55		72.18-97.47	72.74- 93.44	66.69-98.63	93.07-99.46	65.36-95.02	57.99-85.03	78.04-98.09		100
NPV (%)	99.73	100	99.81	95.6	99.81	99.55	99.62	96.44	99.42	100	100
(95% CI)	98.51-99.95		98.92- 99.97	93.43-97.08	98.94-99.97	98.37-99.88	98.61-99.89	94.44-97.73	98.3-99.8	100	100
κ	0.9606	1	0.9274	0.6978	0.9212	0.9757	0.8733	0.639	0.910	1	1
(95% CI)	0.8766-1.045		0.8433- 1.011	0.615 - 0.7807	0.8371 - 1.005	0.8916 - 1.06	0.789-0.957	0.555-0.723	0.826-0.995	1	1

MO: migraine without aura; MA: Migraine with aura; CM: chronic migraine; PM: probable migraine; TTH: tension-type headache; iETTH: infrequent episodic tension-type headache; fETTH: Frequent episodic tension-type headache; CTTH: chronic tension-type headache; PTTH: probable tension-type headache; CH: cluster headache; MOH: medication overuse headache; CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value; κ: Cohen’s kappa.

ISSN: 1129-2377