Figure 4

Subacute treatment with BBG reverses NTG-induced thermal hypersensitivity in wild-type mice, but not in P2X7 knockout mice. Mice were treated for 5 consecutive days with daily doses BBG (50 mg/kg i.p.) or saline and on the fifth day NTG was given 30 min after BBG or saline and then submitted to the ITHT. PWT is expressed in % of baseline. Asterisks indicate significant changes between respective PWT values of saline- and BBG-treated mice (n = 9-16 animals/group; ANOVA + Fischer LSD post hoc test, **P < 0.01).