Figure 1

Experimental plan and experimental groups. TFT: tail flick test. FT: formalin test. DMSO Group: DMSO injected i.p. (2 ml /Kg, i.p.); AM1241 Group: AM1241 (a) (2 mg/kg, i.p.) dissolved in DMSO injected i.p.; AM1241 Group: AM1241 (b) (4 mg/kg, i.p.) dissolved in DMSO injected i.p.; Control Group: vehicle (saline, alcohol and propylene glycole) injected i.p. (3 ml/kg); NTG Group: nitroglycerin (dissolved in saline, alcohol and propylene glycole) injected i.p. at the dose of 10 mg/kg; NTG + DMSO Group: nitroglycerin (10 mg/kg) and DMSO (2 ml/kg) administered i.p.; NTG + AM1241 (a) Group: nitroglycerin (10 mg/kg, i.p.) and AM1241 (2 mg/kg, i.p.) administered i.p.; NTG + AM1241 (b) Group: nitroglycerin (10 mg/kg, i.p.) and AM1241 (4 mg/kg, i.p.) administered i.p.