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Table 2 Comparison of heart rate variability profiles between patients with RCVS in ictal and remission stages and controls

From: Autonomic dysfunction in reversible cerebral vasoconstriction syndromes

  Controls RCVS patients (n = 39)
(n = 39) Ictal stage P value* Remission stage P value* P value**
Time domain variables
SDNN, ms 129.4 ± 34.7 109.9 ± 24.8 0.006 120.7 ± 24.9 0.207 0.041
RMSSD, ms 35.2 ± 14.2 22.1 ± 7.0 <0.001 26.7 ± 11.1 0.005 0.019
pNN 50,% 10.6 ± 8.1 3.7 ± 3.4 <0.001 5.6 ± 6.3 0.003 0.070
Frequency domain variables
Total power, ln (ms2/Hz) 9.01 ± 0.50 8.47 ± 0.48 <0.001 8.71 ± 0.40 0.005 0.008
VLF (0.003 – 0.04 Hz), ln (ms2/Hz) 8.66 ± 0.48 8.21 ± 0.46 <0.001 8.43 ± 0.37 0.017 0.011
LF (0.04 – 0.15 Hz), ln (ms2/Hz) 7.32 ± 0.60 6.63 ± 0.62 <0.001 6.90 ± 0.53 0.001 0.020
HF (0.15 – 0.4 Hz), ln (ms2/Hz) 6.77 ± 0.74 5.82 ± 0.73 <0.001 6.21 ± 0.75 0.001 0.016
LF/HF, ratio 2.48 ± 1.07 3.38 ± 1.32 0.001 2.97 ± 1.25 0.067 0.013
  1. Values presented are mean ± SD.
  2. *Comparison between patients and controls using Student’s t-test. ** Comparison between ictal and remission stage using paired-t test.
  3. HF, High frequency power; LF, low frequency power; pNN50, Percentage of difference of successive interbeat intervals which are larger than 50 ms; RCVS, Reversible cerebral vasoconstriction syndromes; RMSSD, The square root of the mean of the sum of the squares of differences between adjacent normal interbeat intervals; SDNN, Standard deviation of normal inter-beat intervals; VLF, Very low frequency power.