Table 3 Studies on endothelial function by arterial tonometry or vasodilation in response to pharmacological stimuli in migraineurs
Study (First author, year) | Study design | Patients included (n) | % women | Exclusion criteria | Migraine diagnosis | Results |
|---|---|---|---|---|---|---|
Arterial tonometry | Â | Â | Â | Â | Â | Â |
Jiménez-Caballero, 2013 [31] | CC | CM: 21 | 71 | Age ≥50, CVD, inflammatory disease, obesity, HYP, DM, dyslipidemia, CS, active cancer, ovarium pathology, pregnancy or lactation, regular use of vasoactive drugs | ICHD-II | Smaller RHI in migraineurs |
Controls: 21 | ||||||
Liman, 2012 [32] | CC | MwA: 29 | 100 | CVD, obesity, HYP, DM, pregnancy, use of drugs (statins, anticoagulants or antiplatelet and intake of triptans within the previous 24Â h) | ICHD-II | No differences in PAT ratio between migraineurs and controls |
Controls: 30 | ||||||
Vasodilation in response to pharmacological stimuli | ||||||
De Hoon, 2006 [20] | CC | Migraine: 10 | 60 | CVD, HYP, DM, dyslipidemia, CS | ICHD-I | No differences between migraineurs and controls in vasodilation response to serotonin, sodium nitroprusside, and CGRP |
Controls: 10 | ||||||
Edvinsson, 2008 [33] | CC | MwoA: 9 | 78 | None | ICHD-I | No differences between migraineurs and controls in vasodilation response after local heating and iontophoretic administration of acetylcholine, sodium nitroprusside, and CGRP |
Controls: 9 | ||||||
Napoli, 2009 [34] | CC | MwoA: 12 | 58 | HYP, DM, hypercholesterolemia, CVD, CS | ICHD-I | Reduced response to endothelium-dependent vasodilation and production of cGMP in migraineurs; no difference in production of NO |
Controls: 12 | ||||||
Vanmolkot, 2010 [35] | CC | Migraine:16 | 75 | Age >50, CVD, HYP, obesity, DM, CS, dyslipidemia, pregnancy or lactation, use of vasoactive drugs (except OC) | ICHD-II | No differences between migraineurs and controls to sodium nitroprusside, substance P, and NG-monomethyl-L-arginine |
Controls: 16 | ||||||
Yetkin, 2007 [30] | CC | Migraine: 24 | 89 | HYP, CAD, DM, infectious disease | ICHD-I | Higher nitrate-mediated dilation in migraineurs |
| Â | Â | Controls: 26 | Â | Â | Â | Â |