Table 1 Main clinical features of the family members
From: Monozygotic twin sisters discordant for familial hemiplegic migraine
Subject gender/age (yrs) | Onset, remission, (peak) (yrs) | Lifetime occurrence (no. episodes) | Aura | Headache | Accompanying symptoms | Precipitating factors | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Duration (mins) | Type | Location | Laterality | Duration (hrs) | Character/ Intensity | Laterality | |||||
II:4 F/63 | 12 | >50 | 5 | Flickering light | - | Bilateral | 4 | Throbbing/ Severe | Left | Pn, Pt | Stress |
II:6 F/57 | 13 | 1 | 30 | Aphasic; sensitive; perceived limb shape distortions | F, UL | Right | - | - | - | - | - |
II:12 F/52 | 11, 48 | >20 | 10 | Flickering light; forced thinking; sensitive; aphasic; motor | F, UL | Side-shifting or bilateral | 48 | Throbbing/ Severe | Right | N, V, Pn, Pt | Menstruation; stress; minor head trauma |
II:13 F/52 | 22 (45) | >50 | 20 | Scintillating scotoma; sensitive; aphasic | F, T, UL | Side-shifting or bilateral | 48 | Throbbing/ Severe | Side-shifting or bilateral | N, V, Pn, Pt | Hysterectomy |
II:15 F/50 | 18, 47 | >50 | 20 | Flickering light; sensitive; motor; dizziness | F, T, UL | Side-shifting | 12-48 | Throbbing/ Severe | Right | N, V, Pn, Pt | Menstruation; cheese; chocolate; Insomnia |
II:18 F/45 | 18 | >50 | 15 | Scintillating scotoma; sensitive; aphasic; motor; dizziness | F, UL | Side-shifting | 48 | Throbbing/ Severe | Bilateral | N, V, Pn, Pt | Menstruation |
III:1 F/37 | 15 | >20 | 5-10 | Scintillating scotoma | - | Side-shifting | 12 | Throbbing/ Severe | Bilateral | N, V, Pn, Pt | - |
III:3 M/25 | 13 (20) | >20 | 30 | Scintillating scotoma; sensitive; aphasic; motor | UL | Right | 16 | Throbbing/ Severe | Side-shifting | N, V, Pn, Pt | Minor head trauma |
III:4 M/28 | 7, 12 | >20 | - | Dizziness | - | - | 16 | Throbbing/ Severe | Side-shifting | N, Pn, Pt | Stress |
III:8 F/27 | 13 | >50 | 20 | Flickering light; sensitive; aphasic | F, UL | Side-shifting or bilateral | 24-48 | Throbbing/ Severe | Side-shifting (80% right) | N, V, Pn, Pt | Pregnancy; stress |