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Table 2 Differentially expressed proteins identified by Q-TOF LC/MS

From: Discovery by a proteomic approach of possible early biomarkers of drug-induced nephrotoxicity in medication-overuse headache

Protein Entry name a

Protein full name

Acc. no. b

Gene name

Theor. MW c (kDa)

pI

Score d

Pept. e

Seq. cov.(%)f

Over-expressionvs controls g

NSAIDs Triptans Mixtures

High-MW proteins

           

ALBU

Serum albumin

P02768

ALB

66.5

5.67

156

12

53

x

NS

x

UROM(*)

Uromodulin

P07911

UMOD

69.7

4.96

78

23

45

x

x

x

ITIH4(*)

Inter-α-trypsin inhibitor heavy chain H4

Q14624

ITIH4

70.6

5.92

37

5

14

x

NS

x

Medium-MW proteins

           

A1AT

Alpha-1-antitrypsin

P01009

AAT

46.9

5.37

300

37

20

x

NS

x

ACTB

Actin, cytoplasmic1

P60709

ACTB

42.1

5.29

49

20

7

x

x

x

AMBP(*)

Alpha-1-microglobulin

P02760

AMBP

39.9

6.13

261

41

29

x

NS

x

APOH

Apolipoprotein H

P02749

APOH

38.3

8.37

48

12

26

x

NS

NS

SPB3

Serpin B3

P29508

SCCA

44.6

6.35

20

4

16

x

x

x

ANXA1

Annexin A1

P04083

ANX1

38.6

6.64

10

8

8

x

x

x

Low-MW proteins

           

PTGDS

Prostaglandin-H2-D-isomerase

P41222

PTGDS

18.7

8.37

152

25

30

x

x

x

IGKC(*)

Ig kappa chain C region

P01834

IGKC

11.8

5.58

130

14

50

x

NS

x

PGBM

Perlecan (fragment)

P98160

HSPG2

479.2

6.06

405

25

7

x

x

x

TTHY

Transthyretin

P02766

TTR

15.9

5.52

32

19

32

x

NS

NS

SAP

Proactivator polypeptide

P07602

PSAP

9.11

4.22

87

6

6

x

x

x

NTF2

Nuclear transport factor 2

P61970

NUTF2

14.6

5.10

50

8

11

x

x

x

FABP5

Fatty acid-binding protein

Q01469

FABP5

15.5

6.82

83

18

40

x

x

NS

B2MG

Beta-2-microglobulin

P61769

B2M

11.7

6.07

27

4

20

x

x

NS

S10AB

Protein S100-A11

P31949

S100A11

11.8

6.56

96

16

23

x

x

NS

RNAS2(*)

Non-secretory ribonuclease

P10153

RNASE2

18.9

9.10

67

8

19

x

NS

x

CYTC(*)

Cystatin-C

P01034

CST3

13.3

8.75

60

13

26

x

NS

x

S10A8

Protein S100-A8

P05109

S100A8

10.8

6.51

572

170

68

x

x

x

  1. aProtein entry name from UniProt knowledge database. (*)Proteins previously identified as differentially expressed between MOH patients and controls in our previous study.
  2. bPrimary accession number from UniProt database.
  3. cTheoretical protein molecular weight.
  4. dThe highest scores obtained with MASCOT search engine.
  5. eTotal number of peptides that matching the identified proteins.
  6. fSequence coverage: percentage of amino acids sequenced for each detected protein.
  7. gSignificant (x) and not significant (NS) over-expression in each MOH group respect to controls.
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The Journal of Headache and Pain

ISSN: 1129-2377

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