Table 1 The effect of ivabradine 2 mg/kg i.v. on the depolarization shifts and cerebral blood flow induced by cortical spreading depression (3 mg solid KCl)
From: New onset migraine with aura after treatment initiation with ivabradine
Control | Ivabradine | P-value | |
|---|---|---|---|
(n = 8) | (n = 8) | ||
Depolarization shift | |||
- Number of peaks in first hour | 9 ± 2 | 9 ± 1 | 1.000 |
- Amplitude (mV) | 19.7 ± 3.2 | 21.4 ± 3.8 | 0.180 |
- Duration (s) | 46.8 ± 12.6 | 45.0 ± 15.0 | 0.755 |
Cerebral blood flow | |||
- Number of peaks in first hour | 11 ± 1 | 10 ± 1 | 0.323 |
- Amplitude (%change from baseline) | 198 ± 43 | 216 ± 40 | 0.262 |
- Duration (s) | 101.4 ± 47.4 | 117.0 ± 29.4 | 0.395 |