Skip to content

Advertisement

  • Open Access

The genetic regulation of SCN in cluster headache may be affected by Th1/Th2 cytokine derangement

  • ,
  • ,
  • ,
  • ,
  • and
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches1:0001S177.10194

https://doi.org/10.1007/s101940070015

Abstract

T lymphocytes participate not only in immune responses but also in the development of several pathologic reactions. Human T helper cells, on the basis of the cytokines they release, fall into two phenotypes, namely TH1 and TH2. The aim of the present research was to assess whether T lymphocytes are involved in cluster headache pathogenesis. We studied 12 cluster headache patients and 6 control cases in terms of T lymphocyte subsets and their related cytokine release. Our results show that during a cluster headache attack, the TH1 subset is activated, whereas in the periods between and out of the crisis, the TH2 cells become predominant. The possible role played by T lymphocytes and cytokines in the biomolecular phenomenon leading to cluster headache is discussed.

  • Key words T lymphocytes
  • Cytokines
  • Cluster headache
  • Genetic clock regulation

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Please note that comments may be removed without notice if they are flagged by another user or do not comply with our community guidelines.

Advertisement