Skip to main content

Table 2 A short list of syndromic clinical conditions presenting with migraine headache

From: Migraine headache: a review of the molecular genetics of a common disorder

Syndromic migraine Gene (chromosome) involved Migraine features
Familial hemiplegic migraine (FHM) CACNA1 (19p13); ATP1A2 (1q23); SCN1A (2q24); others unknown Attacks of hemiplegic aura
Mitochondrial encephalomyopathy, lactic-acidosis, stroke-like episodes (MELAS) MTTL1 (mtDNA) Recurrent MA, focal neurological deficits, vomiting, convulsions
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) NOTCH3 (19q13.2) MA/MO in 22–40 % of affected patients
Retinopathy, vascular, cerebral and renal involvement, Raynaud and migraine attacks (HERNS) TREX1 (3p21.3) Migraine in most cases
  1. MA migraine with aura, MO migraine without aura