Table 2 A short list of syndromic clinical conditions presenting with migraine headache
From: Migraine headache: a review of the molecular genetics of a common disorder
Syndromic migraine | Gene (chromosome) involved | Migraine features |
|---|---|---|
Familial hemiplegic migraine (FHM) | CACNA1 (19p13); ATP1A2 (1q23); SCN1A (2q24); others unknown | Attacks of hemiplegic aura |
Mitochondrial encephalomyopathy, lactic-acidosis, stroke-like episodes (MELAS) | MTTL1 (mtDNA) | Recurrent MA, focal neurological deficits, vomiting, convulsions |
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) | NOTCH3 (19q13.2) | MA/MO in 22–40 % of affected patients |
Retinopathy, vascular, cerebral and renal involvement, Raynaud and migraine attacks (HERNS) | TREX1 (3p21.3) | Migraine in most cases |