Proteomic analysis of urine in medication-overuse headache patients: possible relation with renal damages

Table 2 Differentially expressed proteins identified by Q-TOF LC/MS analysis

Entry name	Accession n°.	Protein name	Gene name	Score/queries	Cov. (%)	Primary function
UROM	P07911	Uromodulin (or Tamm-Horsfall urinary glycoprotein)	UMOD	8131/525^a	41^a	Regulation
				2781/192^b	32^b
				7532/480^c	39^c
AMBP	P02760	Alpha-1-microglobulin	AMBP	1218/161^b	56^b	Inhibition
ZAZG	P25311	Zinc-alpha-2-glycoprotein	AZGP1	589/53^b	30^b	Lipid degradation
ITIH4	Q14624	Inter-α-trypsin heavy chain H4	ITIH4	500/63^b	42^b	Acute phase reaction
				390/71^c	50^c
IGKC	P01834	Ig kappa chain C region	IGKC	2396/141^b	93^b	Immune response
				2609/142^c	93^c
RNAS2	P10153	Non-secretory ribonuclease	RNASE2	571/51^a	21^a	Multifunction
				468/44^b	21^b
CYTM	Q15828	Cystatin-M	CST6	80/10^a	28^a	Protease inhibitor
CYTC	P01034	Cystatin-C	CST3	172/13^b	23^b	Inhibition/Regulation

Entry name UniProt knowledge database entries, all with extension _HUMAN. Entry names corresponded to those reported in Fig. 2, Accession n° primary accession number from UniProt database, Score: the highest scores obtained using MASCOT search engine, Queries number of peptides that match the identified protein (at least ten matching peptides), Cov. (coverage) percentage of amino acids sequenced for each detected protein
^avalues detected in triptans group
^bvalues detected in NSAIDs group
^cvalues detected in mixtures group

ISSN: 1129-2377