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Table 1 Descriptive demographic, headache and clinical data of control subjects and MOH patients

From: Proteomic analysis of urine in medication-overuse headache patients: possible relation with renal damages

 

Control subjects (n = 16)

Triptans group (n = 18)

NSAIDs group (n = 11)

Mixtures group (n = 14)

Total patients (n = 43)

Age (years)

46.2 ± 5.4*

45.7 ± 10.8*

49.8 ± 7.9

56.7 ± 11.8

48.4 ± 10.5

Gender (F/M)

12/4

16/2

11/0

13/1

40/3

BMI

26.0 ± 3.5

25.3 ± 4.4

23.4 ± 4.4

25.9 ± 6.4

25.1 ± 5.0

DDI

NA

1.2 ± 0.4

1.9 ± 1.4

1.6 ± 0.9

1.5 ± 0.9

MOH duration (years)

NA

7.5 ± 5.8

8.6 ± 7.9

9.0 ± 9.6

8.5 ± 7.6

LDQ

14.3 ± 4.2

15.7 ± 4.5

14.3 ± 6.1

17.2 ± 4.2

15.5 ± 4.8

SBP (mmHg)

116.4 ± 12.7

116.7 ± 15.2

110 ± 10.1

119.2 ± 16.3

115.7±14.1

DBP (mmHg)

70.2 ± 8.5

71.1 ± 11.7

70.0 ± 10.1

71.7 ± 11.7

71.0 ± 10.7

Serum creatinine (mg/dL)

0.6 ± 0.2

0.8 ± 0.1

0.7 ± 0.1

0.7 ± 0.2

0.7 ± 0.1

Serum uric acid (mg/dL)

4.0 ± 1.1

3.8 ± 0.9

3.6 ± 1.3

4.3 ± 1.6

3.9 ± 1.2

Urinary pH

5.3 ± 0.7

5.7 ± 0.8

5.5 ± 0.7

6.2 ± 1.1

5.7 ± 0.9

Urine specific gravity

1013 ± 5

1018 ± 6

1014 ± 6

1012 ± 5

1015 ± 6

  1. Data are expressed as mean ± SD. Statistical significance was evaluated using Student’s t-test (* P < 0.01 vs. mixtures group. P = 0.008 after Bonferroni correction)
  2. Groups: triptans (exclusively one, or more types of triptans), NSAIDs (exclusively one, or more types of NSAIDs), mixtures (consumption of drugs containing indometacin, caffeine and sedatives)
  3. BMI body mass index, DDI daily drug intake, MOH medication-overuse headache, LDQ Leed’s drugs questionnaire, SBP systolic blood pressure, DBP dyastolic blood pressure