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Table 4 Outcome after 1 year of follow-up

From: Orbitofrontal dysfunction predicts poor prognosis in chronic migraine with medication overuse

 

Positive outcome (n = 51)a

Negative outcome (n = 27)b

p

Orbitofrontal tasks

 Faux-Pas (FP)

  FP Composite Score

46 (0–60)

39 (0–52)

0.0054

  Detected FP

9 (0–10)

8 (0–10)

0.0176

  Who committed the FP

8 (0–10)

7.5 (0–10)

0.0329

  Why is it a FP

8 (0–10)

7 (0–10)

0.0336

  Why someone did the FP

6 (0–10)

4 (0–8)

0.0087

  Intentionality

7 (0–10)

5 (0–9)

0.0134

  Empathy

8 (0–10)

7 (0–10)

0.0150

Reading the Mind in the Eyes

27 (17–32)

23 (14–31)

0.0018

Empathy Quotient

45 (31–65)

44.5 (20–60)

0.0368

Dorsolateral tasks

 Trail Making B

68 (30–203)

79.5 (39–210)

0.0803

 Letters and Numbers

10 (4–20)

9.5 (4–19)

0.4009

WCST

 Categories acquired

4 (0–5)

3 (0–5)

0.0584

 Perseverative errors

6 (3–29)

7 (2–20)

0.4625

 First category

11 (10–65)

12 (10–65)

0.0112

Beck Depression Inventory

8.5 (0–27)

15.5 (1–44)

0.0010

Beck Anxiety Inventory

10 (0–43)

17.5 (2–51)

0.0053

Zuckerman–Kuhlman personality questionnaire

 Impulsive sensation seeking

3 (0–11)

4.5 (0–15)

0.8960

 Neuroticism–anxiety

8 (0–16)

11.5 (1–19)

0.0384

 Aggression–hostility

6 (0–13)

7.5 (3–14)

0.2075

 Activity

7 (1–16)

6 (1–14)

0.8264

 Sociability

6 (0–14)

4.5 (0–9)

0.0805

 Infrequency

1 (0–8)

1 (0–6)

0.4290

  1. Values expressed as median (range)
  2. aPatients with chronic headache that stopped medication overuse and patients with episodic headache who persisted without overuse
  3. bPatients with chronic headache that persisted overusing medication and patients with episodic headache who converted into chronic migraine with medication overuse