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Table 1 Genotype and Allele Frequencies of the HCRTR1 polymorphisms in migraine patients and controls

From: Evidence for an association between migraine and the hypocretin receptor 1 gene

 

GF

AF

HCRTR1 SNP1 rs10914456

C/C (%)

C/T (%)

T/T (%)

C (%)

T (%)

 Controls

108 (41.7)

122 (47.1)

29 (11.2)

338 (65.3)

180 (34.7)

 Migraine patients

146 (38.1)

188 (49.0)

50 (13.0)

480 (62.5)

288 (37.5)

HCRTR1 SNP2 rs4949449

G/G (%)

G/T (%)

T/T (%)

G (%)

T (%)

 Controls

104 (40.2)

129 (49.8)

26 (10.0)

337 (60.6)

181 (39.4)

 Migraine patients

147 (38.3)

190 (49.5)

47 (12.2)

484 (63.0)

284 (37.0)

HCRTR1 SNP3 rs2271933

G/G (%)

G/A (%)

A/A (%)

G (%)

A (%)

 Controls

125 (53.3)

108 (41.7)a

26 (10.0)a

358 (69.1)

160 (30.9)b

 Migraine patients

138 (36.0)

194 (50.5)

52 (13.5)

470 (61.2)

298 (38.8)

  1. p values were calculated by the χ2 test from 3×2 (genotype) or 2×2 (allele) contingency tables
  2. GF genotypic frequency, AF allelic frequency
  3. a GF χ2 = 9.872, p = 0.007, power = 0.819
  4. b AF χ2 = 8.108, p = 0.004, power = 0.828