Optimal balance of efficacy and tolerability of oral triptans and telcagepant: a review and a clinical comment

Table 1 Efficacy and tolerability of triptans and telcagepant

Drug and dose (mg)	Efficacy (+, ++, and +++)	Adverse events potential (0, +, ++, and +++)
Subcutaneous sumatriptan: 6	+++	+++
Sumatriptan: 50	++	+
Sumatriptan: 100	++	++
Naratriptan: 2.5	+	0
Rizatriptan: 10	++	++
Zolmitriptan: 2.5	++	++
Eletriptan: 40	++	++
Almotriptan: 12.5	++	0
Frovatriptan: 2.5	+	+
Telcagepant: 300	++	0

For explanation of (+ to +++) for efficacy and of (0 to +++) for AES potential, see text. The rating is based on [13, 15, 21, 23, 27, 30]

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