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Table 4 Outcome in seven studies with follow-up ≥ 4 years

From: A 4-year follow-up of patients with medication-overuse headache previously included in a randomized multicentre study

Publication year (reference)

Dropout rate (%)

Headache days/month baseline

Duration of follow-up (years, mean)

Headache days/month Follow-up

Responder rate1 (%)

Relapse rate (%)

Statistical significant predictors

1996 [13]Ba

30

5

50A

40

Number of tablets, duration of drug abuse

1999 [15]Ba

61

5.9

12.3

21

Sex, type of overused drugs

2001 [16]Bd

12

4

60

Number of tablets, duration of drug abuse

2001 [12]Bd

9.3

351

33

None

2004 [14]Ba

22

4

45

Headache type, type of overused drugs

2009 [11]Bb

45

26.1

5

11.3

78

None

2010 [17]Bc

6

4

44

Remission at year 1

Mean

29

26.1

5.3

11.8

54

41

 
  1. AHeadache ≤8 days or less without medication overuse
  2. BMOH diagnosis based on: (a) First version of the International Headache Society (IHS) from 1988 (ICDH-1), (b) criteria proposed by Silberstein and Lipton in 2000, (c) ICDH-2 or later versions, or (d) other criteria or not clearly stated