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Table 2 Efficacy variables (with 95% confidence intervals) at baseline, 5 months and 4 years’ follow-up

From: A 4-year follow-up of patients with medication-overuse headache previously included in a randomized multicentre study

 

Baseline

5 months

4 years

Headache days/month (n = 50)

25.0 (23.2–26.7)

21.6 (18.9–24.4)*

18.4 (15.1–21.8)***

Days with acute headache drugs/month (n = 50)

22.9 (21.0–24.8)

13.3 (10.4–16.3)***

13.4 (10.3–16.4)***

Headache hours/month (n = 50)

8.1 (6.8–9.4)

8.3 (7.1–9.6)

7.7 (6.2–9.2)

Headache index/month (n = 50)

449 (349–548)

420 (306–534)

320 (224–418)***

Days with sick leave/month (n = 35)

6.3 (1.7–11.0)

2.2 (0.3–4.2)*

0.9 (0.2–1.6)**

Mental health component (MCS-12) (n = 38)

51.2 (44.6–57.7)

57.9 (50.8–64.9)**

62.7 (53.8–71.6)**

Physical health component (PCS-12) (n = 38)

46.7 (40–53.1)

51.0 (43.5–58.5)*

59.8 (51.0–68.6)**

Number of prophylactic drugs tried, mean (n = 50)

1.2 (0.8–1.6)

1.9 (1.4–2.3)***

2.5 (2.0–3.0)***

  1. *** p ≤ 0.001; ** p ≤ 0.01; * p < 0.05