Table 2 Recommendations of the DMKG, DGN, ÖKG and SKG for self-medication of acute migraine attacks with and without aura
Drug or fixed-dose combination | Quality of scientific evidence | Scientific evidence of efficacy | Clinical impression of effectiveness | Clinical impression of tolerability | Comments | Recommendation for self-medication |
|---|---|---|---|---|---|---|
Two tablets of the fixed combination: (250–265 mg) acetylsalicylic acid + (200–265 mg) paracetamol + (50–65 mg) caffeine | A | +++ | ++ | +++ | Highlighted recommendation on the basis of the analysed comparative studies | Drug of first choice |
Acetylsalicylic acid (900–1,000 mg) | A | +++ | ++ | ++ | As tablet and as effervescent tablet | Drug of first choice |
Ibuprofen (400 mg) | A | +++ | ++ | +++ | Drug of first choice | |
Naratriptan (2.5 mg) | A | ++ | ++ | +++ | Drug of first choice | |
Paracetamol (1,000 mg) | A | ++ | + | +++ | Drug of first choice | |
Phenazone (1,000 mg) | A | ++ | ++ | ++ | Drug of first choice | |
Acetylsalicylic acid + paracetamol | C | (+) | ++ | + | Only in individual cases | |
Naproxen resp. naproxen-sodium | D | 0 | + | ++ | Efficacy from 200 mg to 250 mg naproxen or naproxen-sodium is not proven | Only in individual cases |
Acetylsalicylic acid + vitamin C | D | 0 | ++ | ++ | ASA dose per tablet at least 400 mg | Only in individual cases |
Phenazone-containing combinations | D | 0 | + | ++ | Only in individual cases | |
Propyphenazone (also combinations) | D | 0 | + | ++ | Only in individual cases |