Fig. 2
Effect of COX inhibitors on repeated CGRP (0.33 μg kg−1min−1 over 3 min intra-arterial) induced vasodilations in intravital microscopy. After the baseline response was established one of the drugs (indomethacin 5 mg kg−1, naproxen 30 mg kg−1 or ibuprofen 30 mg kg−1) was applied intravenously, followed by four further CGRP infusions with a 17 min recovery period, starting 10 min after the administration of one of the drugs. None of the drugs altered the vessel response to CGRP infusion