Fig. 1
Effect of COX inhibitors on electrical stimulation induced vasodilation of the middle meningeal artery in intravital microscopy. After the baseline response was established one of the drugs (indomethacin 5 mg kg−1, naproxen 30 mg kg−1 or ibuprofen 30 mg kg−1) was applied intravenously, followed by four further electrical stimulations with a 15 min recovery period, starting 10 min after the administration of one of the drugs. Each of the administered drugs was able to significantly attenuate neurogenic vasodilation. *P < 0.05