Table 1 Characteristics of included studies investigating the association between the SLC6A4 STin2 VNTR polymorphism and migraine
From: STin2 VNTR polymorphism in the serotonin transporter gene and migraine: pooled and meta-analyses
Author and year | Country | Setting | Population | Study size with genotypic information | Comment | |||
|---|---|---|---|---|---|---|---|---|
Controls | Any migraine | MA | MO | |||||
Ogilvie [10] | Denmark | Population | Mixed | 133 | 285 | 94 | 173 | |
Lea [13] | Australia | Population | Mixed | 141 | 148 | 81 | 67 | Other polymorphisms investigated: in dopamine beta-hydroxylase gene (DBH) and dopamine receptor 2 gene (DRD2). |
Yilmaz [9] | Turkey | NS | Mixed | 79 | 37 | – | – | Other polymorphisms investigated: SLC6A4 5-HTTLPR. |
Racchi [11] | Italy | Clinic | Mixed | 32 | – | 44 | – | Other polymorphisms investigated: HTR1B 261 T > G, HTR1B 861 G > C, HTR2C 68 G > C. MA patients were compared to unaffected family members and unrelated controls. For the present analysis, only data from MA patients and unaffected controls are considered. |
Szilagyi [12] | Hungary | Clinic | Mixed | 464 | 87 | 38 | 49 | Other polymorphisms investigated: SCL6A4 5-HTTLPR. Cases were children and adolescents; controls were high school and university students. |
Total number of subjects | 849 | 557 | 257 | 289 | ||||