Table 4 Genotypic and allelic frequencies of VNRT-2 polymorphism in controls, migraine without aura and without drug overuse (MO) and medication overuse headache (MOH)
From: Lack of association between five serotonin metabolism-related genes and medication overuse headache
|  | Controls (n = 104) | MO (n = 86) | MOH (n = 101) |
|---|---|---|---|
n (%) | n (%) | n (%) | |
VNRT-2 polymorphism: STin 2.8-2.9-2.12 genotype | |||
 8/12 | 3 (0.03) | 1 (0.01) | 3 (0.03) |
 9/9 | 21 (0.20) | 17 (0.20) | 23 (0.23) |
 9/12 | 38 (0.37) | 42 (0.49) | 32 (0.32) |
 12/12 | 41 (0.39) | 26 (0.30) | 42 (0.42) |
 8/9 | 1 (0.01) | 0 (0.00) | 1 (0.01) |
MO versus controls | χ2 = 4.734 (P = 0.316) | ||
MOH versus controls | χ2 = 0.574 (P = 0.966) | ||
MOH versus MO | χ2 = 7.287 (P = 0.121) | ||
VNRT-2 polymorphism: STin 2.8-2.9-2.12 alleles | |||
 8 | 4 (0.02) | 1 (0.006) | 4 (0.019) |
 9 | 81 (0.39) | 79 (0.44) | 81 (0.39) |
 12 | 123 (0.60) | 95 (0.55) | 123 (0.60) |
MO versus controls | χ2 = 2.28 (P = 0.320) | ||
MOH versus controls | χ2 = 0.01 (P = 0.998) | ||
MOH versus MO | χ2 = 2.27 (P = 0.321) | ||