From: New drugs for migraine
Study | N | Dose and application | Result | |
---|---|---|---|---|
Silberstein [124] | 122 | 25 and 75 U, forehead and temples | Fixed sites | 25 U showed better effect than placebo, not 75 U group |
Evers [125] | 60 | 16U in forehead, 100U in forehead and neck | Fixed sites | No difference between groups |
Elkind [127] | 418 | 25 and 50 U in front and sides of head | Fixed sites | No difference between groups |
Aurora [126] | 369 | 110−260 U | “Follow the pain” | No difference between groups |
Relja [128] | 495 | 75, 150, 225 U in various head and neck muscles | Fixed sites | No difference between groups |
Cady [129] | 61 | 139 U, in various head and neck muscles | Fixed sites | No significant differences in headache frequency, but with regard to headache impact measure |