New drugs for migraine

Table 2 Efficacy and adverse events of telgacepant and triptans

Study	Type of drug	Pain relief at 2 h (%)	Pain free at 2 h (%)	2–24 h sustained pain freedom (%)	Placebo-substracted AE (%)	Adverse events (%)
Ho et al. [88]*	Telcagepant 300 mg	68.1	45.2	32.0		35.3
	Telcagepant 400 mg	48.2	24.3	22.0		36.5
	Telcagepant 600 mg	67.5	32.1	39.6		40.8
	Telcagepant 10 mg	69.5	33.4	18.4		42.0
	Placebo	46.3	14.3	11.0		36.2
Ho et al. [87]	Telcagepant 150 mg	49.8	17.2	10.7		31
	Telcagepant 300 mg	55.0	26.9	20.2.4		37
	Zolmitriptan 5 mg	56.4	31.3	18.2		51
	Placebo	27.7	9.6	5.0		32
Meta-analyses 2002	Sumatriptan 100 mg	59 (57–60)	29 (27–30)		13 (8–18)
	Almogran 12.5 mg	58
	Rizatriptan 10 mg	Ca. 70	37
	Elitriptan 20 mg	Ca. 68	Ca. 40
	Zolmitriptan 5 mg	>60	42 (36–48)

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