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Table 2 Effect of indomethacin, prochlorperazine, caffeine, Indoprocaf and sumatriptan in mouse abdominal constriction test, with and without pertussis toxin (PTX) (mean ± SEM)

From: The central analgesia induced by antimigraine drugs is independent from Gi proteins: superiority of a fixed combination of indomethacin, prochlorperazine and caffeine, compared to sumatriptan, in an in vivo model

 

No. of abdominal constrictions

Saline/saline

PTX/saline

Saline/drug

PTX/drug

Indomethacin (1 mg/kg, s.c.)

31.4 ± 4.2

33.5 ± 2.3

16.1 ± 3.3*

13.8 ± 3.7°

Prochlorperazine (1 mg/kg, s.c.)

27.1 ± 3.3

31.6 ± 2.4

15.1 ± 2.6*

16.6 ± 3.0°

Caffeine (3 mg/kg, s.c.)

30.1 ± 1.3

31.5 ± 4.1

14.8 ± 3.3*

17.5 ± 2.9°

Sumatriptan (20 mg/kg, s.c.)

28.6 ± 3.7

29.8 ± 3.1

13.2 ± 2.9*

14.4 ± 2.7°

Indoprocaf (1/1/3 mg/kg, s.c.)

28.3 ± 1.6

27.8 ± 2.0

3.9 ± 1.1*§

5.5 ± 1.7°^

  1. * P < 0.01 vs. the corresponding saline/saline
  2. ° P < 0.01 vs. the corresponding PTX/saline
  3. §P < 0.01 vs. Saline/Indomethacin or saline/prochlorperazine or saline/caffeine or saline/sumatriptan
  4. ^ P < 0.01 vs. PTX/indomethacin or PTX/prochlorperazine or PTX/caffeine or PTX/sumatriptan
  5. ANOVA
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The Journal of Headache and Pain

ISSN: 1129-2377

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